In Silence players accompany Noah who struggles to find his little sister Renie in the turmoil of war. Against all odds, he manages to follow her, only to find himself alone in Silence, the world he once traveled as Sadwick the clown. There seems to be no way back and Renie is lost in a war-ravaged Silence.
Together with his sister he joins a group of rebels, led by a determined girl named Kyra. They're the last bastion of resistance against the terrible seekers - mysterious creatures washing over Silence in ever growing numbers, while more and more of the people just seem to vanish. It is on Noah and the player to find a way back home from this dangerous place.